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THE HUNT FOR RED OCTOBER .Promising allosteric inhibition of PKR by a novel synthetic peptide.
PKR is a protein kinase that is activated by binding of dsRNA to its N-terminal regulatory domain. As a consequence of its activation, PKR phosphorylates its eukaryotic initiation factor-2 alpha subunit (eIF-2 alpha), triggering shut-off of translation and initiation of cell death, apoptosis. As a result of its pro-apoptotic function, PKR is implicated in the development of many diseases, including neurodegenerative and infectious diseases. PKR is also activated by pathogens, such as HIV-1, and this activation results in the switch of viral replication from translation to gene expression. Here, we describe the design, synthesis and evaluation of a novel peptide inhibitor of PKR that has shown promising in vitro inhibition of the enzyme.Genetics of excitatory synaptic transmission in the central nervous system.
During the last decade, the number of genes that contribute to the excitatory synaptic transmission in the central nervous system has been considerably increased, and gene identification has progressed considerably. However, a large proportion of the genes remain to be identified and characterized. The present review focuses on genes that are known 0b46394aab